Effects of Four Weeks of Aerobic Exercise Training with Complementary Probiotic Supplementation on Serum SOD and TAC Levels in Type 2 Diabetes of Male Rats

Background and Objectives: Deficiency Glucose Intake Impaired Antioxidant Capacity. Aerobic Exercise Combined with Probiotic Supplementation Regulates Glucose Intake in Diabetic Patients. Purpose of this study was to investigate effects of four weeks of aerobic exercise training with complementary probiotic supplementation on serum SOD and TAC levels in type 2 diabetes of male rats.  Materials & Methods: The present study was an experimental study. In general, 32 diabetic male rats were divided into five major groups of healthy NC control (n = 6), DC diabetic control (n = 6), SDC diabetic supplement control (n = 6), TD diabetic exercise group (n = 7) and STD diabetic exercise supplement (n = 7). After induction of diabetes, a probiotic supplement was used for 4 w. After the mice were anesthetized, blood serum was received directly from the animal left ventricle. ELISA method and comparison of groups by (2-way ANOVA) at an alpha level of 0.05 were used to calculate SOD levels and total TAC capacity. Results: Changes in TAC levels in SDT group in comparison to DT, DC and NC groups (p = 0.02 and p = 0.03) were significant (p = 0.001), respectively. The DT and SDC groups were significantly different from DC group. Changes in SOD levels of the SDT group in comparison to DC and NC groups were significant (p = 0.01 and p = 0.03), respectively. Conclusion: Results of the present study showed that four weeks of aerobic exercise in combination with probiotic supplementation decreased glucose levels in diabetic mice. Furthermore, aerobic exercise increased TAC in diabetic mice and SOD values affected by exercise and supplementation could possibly improve oxidative defense in diabetic patients.